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2000 5
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Viral infection of the lung: host response and sequelae.
Yoo JK, Kim TS, Hufford MM, Braciale TJ. Yoo JK, et al. J Allergy Clin Immunol. 2013 Dec;132(6):1263-76; quiz 1277. doi: 10.1016/j.jaci.2013.06.006. Epub 2013 Aug 1. J Allergy Clin Immunol. 2013. PMID: 23915713 Free PMC article. Review.
Bronchoalveolar lavage cytokine patterns in children with severe neutrophilic and paucigranulocytic asthma.
Steinke JW, Lawrence MG, Teague WG, Braciale TJ, Patrie JT, Borish L. Steinke JW, et al. J Allergy Clin Immunol. 2021 Feb;147(2):686-693.e3. doi: 10.1016/j.jaci.2020.05.039. Epub 2020 Jun 9. J Allergy Clin Immunol. 2021. PMID: 32526308 Free PMC article.
Cytokines specifically responsible for T(h)17 (IL-17, IL-6, G-CSF) and T(h)1 differentiation and expression (IL-12, TNF-alpha, IFN-gamma) were enhanced in the neutrophilic cohorts. ...CONCLUSIONS: The results demonstrate that children with refractory asthma and neut …
Cytokines specifically responsible for T(h)17 (IL-17, IL-6, G-CSF) and T(h)1 differentiation and expression (IL-12, TNF-alpha, …
Cytokine-dependent induction of CD4+ T cells with cytotoxic potential during influenza virus infection.
Hua L, Yao S, Pham D, Jiang L, Wright J, Sawant D, Dent AL, Braciale TJ, Kaplan MH, Sun J. Hua L, et al. J Virol. 2013 Nov;87(21):11884-93. doi: 10.1128/JVI.01461-13. Epub 2013 Aug 28. J Virol. 2013. PMID: 23986597 Free PMC article.
The development of CD4(+) T cells with cytotoxic potential in vivo was dependent on the cooperation of the STAT2-dependent type I interferon signaling and the interleukin-2/interleukin-2 receptor alpha pathway for the induction of the transcription factors T-bet and …
The development of CD4(+) T cells with cytotoxic potential in vivo was dependent on the cooperation of the STAT2-dependent type I int …
Preferential migration of effector CD8+ T cells into the interstitium of the normal lung.
Galkina E, Thatte J, Dabak V, Williams MB, Ley K, Braciale TJ. Galkina E, et al. J Clin Invest. 2005 Dec;115(12):3473-83. doi: 10.1172/JCI24482. Epub 2005 Nov 23. J Clin Invest. 2005. PMID: 16308575 Free PMC article.
The respiratory tract is a primary site of infection and exposure to environmental antigens and an important site of memory T cell localization. We analyzed the migration and retention of naive and activated CD8+ T cells within the noninflamed lungs and quantitated …
The respiratory tract is a primary site of infection and exposure to environmental antigens and an important site of memory T cell lo …
Liver-resident CD103+ dendritic cells prime antiviral CD8+ T cells in situ.
Krueger PD, Kim TS, Sung SS, Braciale TJ, Hahn YS. Krueger PD, et al. J Immunol. 2015 Apr 1;194(7):3213-22. doi: 10.4049/jimmunol.1402622. Epub 2015 Feb 23. J Immunol. 2015. PMID: 25712214 Free PMC article.
To determine the contribution of hepatic dendritic cells (DCs) in the activation of naive CD8(+) T cells, we first characterized resident DC subsets in the murine liver. ...Limiting DC migration out of the liver does not significantly alter CD8(+) T cell responsiven …
To determine the contribution of hepatic dendritic cells (DCs) in the activation of naive CD8(+) T cells, we first characterized resi …
Stimulation of naive CD8+ T cells by a variant viral epitope induces activation and enhanced apoptosis.
Ream RM, Sun J, Braciale TJ. Ream RM, et al. J Immunol. 2010 Mar 1;184(5):2401-9. doi: 10.4049/jimmunol.0902448. Epub 2010 Feb 5. J Immunol. 2010. PMID: 20139280 Free PMC article.
Classically, naive T cells recognize a specific peptide-MHC complex resulting in their activation and differentiation. ...These altered peptide ligands have been shown to trigger responses ranging from complete activation to full inhibition of T cell responses, and …
Classically, naive T cells recognize a specific peptide-MHC complex resulting in their activation and differentiation. ...These alter …
Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection.
Yoon H, Legge KL, Sung SS, Braciale TJ. Yoon H, et al. J Immunol. 2007 Jul 1;179(1):391-9. doi: 10.4049/jimmunol.179.1.391. J Immunol. 2007. PMID: 17579060
We have used a TCR-transgenic CD8+ T cell adoptive transfer model to examine the tempo of T cell activation and proliferation in the draining lymph nodes (DLN) in response to respiratory virus infection. The T cell response in the DLN differed for mice infect …
We have used a TCR-transgenic CD8+ T cell adoptive transfer model to examine the tempo of T cell activation and proliferation …
Partial activation of foreign antigen specific T lymphocytes by a self peptide: possible roles of altered peptide ligands in regulating T lymphocyte mediated immune response.
Cao W, Braciale TJ. Cao W, et al. J Mol Med (Berl). 1996 Oct;74(10):573-82. doi: 10.1007/s001090050061. J Mol Med (Berl). 1996. PMID: 8912178 Review.
T cell interaction with antigenic peptides leads to signal transduction and activation events in the effector cells. Recent studies of T cell responses to subtle variants of antigenic peptides can lead to alterations in the activation state of T cells. ...
T cell interaction with antigenic peptides leads to signal transduction and activation events in the effector cells. Recent studies o …
Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection.
Graham MB, Braciale VL, Braciale TJ. Graham MB, et al. J Exp Med. 1994 Oct 1;180(4):1273-82. doi: 10.1084/jem.180.4.1273. J Exp Med. 1994. PMID: 7931062 Free PMC article.
T lymphocytes play a primary role in recovery from viral infections and in antiviral immunity. ...The ability to further dissect the role that CD4+ T cells play in the immune response to a number of pathogens has been greatly enhanced by evidence for more extensive …
T lymphocytes play a primary role in recovery from viral infections and in antiviral immunity. ...The ability to further dissect the …
Incomplete CD8(+) T lymphocyte differentiation as a mechanism for subdominant cytotoxic T lymphocyte responses to a viral antigen.
Spencer JV, Braciale TJ. Spencer JV, et al. J Exp Med. 2000 May 15;191(10):1687-98. doi: 10.1084/jem.191.10.1687. J Exp Med. 2000. PMID: 10811862 Free PMC article.
CD8(+) cytotoxic T lymphocytes (CTLs) recognize antigen in the context of major histocompatibility complex (MHC) class I molecules. ...In contrast, stimulation of memory CD8(+) T lymphocytes directed to the subdominant HA210-219 epitope results in the generation of …
CD8(+) cytotoxic T lymphocytes (CTLs) recognize antigen in the context of major histocompatibility complex (MHC) class I molecules. . …
92 results